INFINITI CYP2C19 Assay
- CYP450 2C19: *2, *3, *17
- Multiplexed determination of 3 genetic variants.
Sample Type and Volume:
- Uses 0.2 - 2.0 mL of peripheral whole blood in EDTA (purple top) tube.
- Genetic polymorphisms in CYP2C19 are common and can affect therapeutic response to drugs; ranging from poor metabolizers to ultra-rapid metabolizers.
- The most common poor metabolizer phenotypes have been identified as CYP2C19*2 and CYP2C19*3.
- CYP2C19*17 is the one phenotype that has an opposite effect. CYP2C19*17 has been reported to be associated with ultra-rapid CYP2C19 activity.
- CYP2C19 is involved in the metabolism and elimination of many commonly prescribed drugs including antidepressants, anti-epileptics, barbiturates, and proton inhibitors.
- Detecting genetic variations in drug-metabolizing enzymes is useful for identifying individuals who may experience adverse drug reactions with conventional doses of certain medications.
- Adjustment of therapeutic strategy could be beneficial based upon knowledge of these differences in metabolism.
- Desta Z et al Clinical Significance of the cytochrome P450 2C19 polymorphism. Clin Pharmacokinet 2002; 41:913-58
- Sim SC et al A common novel CYP2C19 gene variant causes ultra-rapid drug metabolism relevant for the drug response to proton pump inhibitors and anti-depressents. Clin Pharmacol Ther. 2006; 79:103-113
- Rudberg l et al Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients. Clin Pharmacol Ther. 2008 Feb;83(2):322-7