INFINITI CYP450 2D6-BC Assay

  • The INFINITI CYP450 2D6-BC Assay is CE Marked.

  • The INFINITI CYP450 2D6-BC is indicated for use as an aid to clinicians in determining therapeutic strategy for therapeutics that are metabolized by the CTP450 2D6 gene product.

  • The INFINITI CYP450 2D6-BC utilizes the CYP450 2D6-BC Intellipac, CYP450 2D6-BC Amp Mix and CYP450 2D6-BC BioFilmChip Microarray.

  • The INFINITI CYP450 2D6-BC Assay is automated by the INFINITI Analyzer.

Analytes Detected: 
  • *2 (2850C>T)       *7 (2935A>C)                          *17 (1023C>T)
  • *2A (-1584C>G)  *8 (1758G>T)                           *29 (1659G>A)
  • *3 (2549delA)      *9 (2615_2617delAAG)           *41 (2988G>A)
  • *4 (1846G>A)     *10 (100C>T)                           *XN (multiple)
  • *5 (deletion)        *12 (124G>A)                          
  • *6 (1707delT)      *14 (1758G>A) 
Features: 
  • Multiplexed determination of 16 genetic variants on one BioFilmChip Microarray
  • Customized reports
  • Load & Go automated on the INFINITI/INFINITI PLUS Analyzer.
  • Replicate determinations on a single BioFilmChip Microarray ensures quality results.
Sample Type and Volume: 
  • Uses 0.2 - 2.0 mL of peripheral whole blood in EDTA (purple top) tube.
  • Requires 50 ng DNA / reaction
Clinical Relevance: 
  • CYP450 2D6 is the member of the cytochrome P450 (CYP450) family that is responsible for the metabolism of most xenobiotics found in the body.1
  • This class of compounds is variable in nature but include common products such as antibodies, which are used by young and old alike for many ailments, ranging from the flu to other more serious maladies like cancers.
Clinical Utility: 
  • While the CYP2D6 gene has a wide variety of substrates, it also has a considerable number of genetic variants, making its genetic profiling very important due to the high number of polymorphic possibilities.
  • Its variants ultimately divide those carrying the polymorphism into four grades of metabolisers: poor (little to no 2D6 function), intermediate (below average 2D6 function), extensive (normal 2D6 function), and ultrarapid (excess expression of the 2D6 protein and thus much greater metabolic ability than normal 2D6 function).2
  • In addition, like the CYP450 2C19 gene, the CYP2D6 genome also exhibits significant racial heterogeneity. The bulk of the polymorphisms occur in non-Asiatic populations, with approximately 10% in Caucasians whereas only 2% in Asians.1
  • In spite of this apparent lack of importance in Asian genetics, it has been found that approximately 50% of Asiatic peoples will exhibit a polymorphism on the CYP450 2D6 gene that gives a slightly lower than normal 2D6 function.1
References: 
  1. Australian Medicines Handbook (AMH) 2004
  2. McLellan RA, Oscarson M, Seidegård J, Evans DA, Ingelman-Sundberg M.; Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. Pharmacogenetics 7 (3): 187–91.

CYP450 2D6-BC CE