INFINITI Factor II Assay
The INFINITI Factor II Assay is CE Marked.
The INFINITI Factor II is indicated for use as an aid to diagnosis in the evaluation of patients with suspected thrombophilia.
The INFINITI Factor II is used to determine genetic variants in Factor II (Prothrombin).
The INFINITI Factor II utilizes the Factor II Intellipac, Factor II Amp Mix and Factor II BioFlimChip Microarray.
The INFINITI Factor II Assay is automated by the INFINITI Analyzer.
- Factor II (Prothrombin) G20210A
- Determination of genetic variant for Factor II.
Rapid turnaround time enhances workflow efficiency.
Load & Go automated on the INFINITI/INFINITI PLUS Analyzer.
Replicate determinations on a single BioFilmChip Microarray ensures quality results.
Sample Type and Volume:
- Requires 0.2 - 2.0 ml of peripheral whole blood in EDTA (purple-top) tube
- 50 ng DNA / reaction.
- The Factor II (Prothrombin) variant gene is the second most common genetic defect for inherited thrombosis.
- The increased risk of venous thrombosis in patients who are heterozygous for the prothrombin (G20210A) gene polymorphism is 3-fold.1
- Homozygotes for this polymorphism have been described but are very uncommon.1
- Patients with a previous, or current, thrombotic event that have the prothrombin (G20210A) gene polymorphism are potentially at increased risk for recurrence.1
- Patients with the prothrombin (G20210A) mutation are at increased risk of thrombosis when exposed to other risk factors such as:
- (1) smoking
- (2) pregnancy
- (3) Obesity
- (4) Oral Contraceptives
- (5) Immobility1
- "The risk of thrombosis is substantially increased for patients with multiple genetic risk factors (i.e., the "double hithypothesis") including the prothrombin (G20210A) gene mutation, Factor V Leiden Leiden mutation, hyperhomocysteinemia, methylenetetrahydrofolate reductase (MTHFR) thermolabile polymorphism, protein C deficiency, protein S deficiency, and antiphospholipid antibody syndrome(s)."1
- Definition and confirmation of the prothrombin (G20210A) gene polymorphism is necessary for genetic counseling of patients for themselves and family members.1