INFINITI Factor II Assay
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The INFINITI Factor II Assay is CE Marked.
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The INFINITI Factor II is indicated for use as an aid to diagnosis in the evaluation of patients with suspected thrombophilia.
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The INFINITI Factor II is used to determine genetic variants in Factor II (Prothrombin).
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The INFINITI Factor II utilizes the Factor II Intellipac, Factor II Amp Mix and Factor II BioFlimChip Microarray.
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The INFINITI Factor II Assay is automated by the INFINITI Analyzer.
Analytes Detected:
- Factor II (Prothrombin) G20210A
Features:
- Determination of genetic variant for Factor II.
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Rapid turnaround time enhances workflow efficiency.
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Load & Go automated on the INFINITI/INFINITI PLUS Analyzer.
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Replicate determinations on a single BioFilmChip Microarray ensures quality results.
Sample Type and Volume:
- Requires 0.2 - 2.0 ml of peripheral whole blood in EDTA (purple-top) tube
- 50 ng DNA / reaction.
Clinical Relevance:
- The Factor II (Prothrombin) variant gene is the second most common genetic defect for inherited thrombosis.
Clinical Utility:
- The increased risk of venous thrombosis in patients who are heterozygous for the prothrombin (G20210A) gene polymorphism is 3-fold.1
- Homozygotes for this polymorphism have been described but are very uncommon.1
- Patients with a previous, or current, thrombotic event that have the prothrombin (G20210A) gene polymorphism are potentially at increased risk for recurrence.1
- Patients with the prothrombin (G20210A) mutation are at increased risk of thrombosis when exposed to other risk factors such as:
- (1) smoking
- (2) pregnancy
- (3) Obesity
- (4) Oral Contraceptives
- (5) Immobility1
- "The risk of thrombosis is substantially increased for patients with multiple genetic risk factors (i.e., the "double hithypothesis") including the prothrombin (G20210A) gene mutation, Factor V Leiden Leiden mutation, hyperhomocysteinemia, methylenetetrahydrofolate reductase (MTHFR) thermolabile polymorphism, protein C deficiency, protein S deficiency, and antiphospholipid antibody syndrome(s)."1
- Definition and confirmation of the prothrombin (G20210A) gene polymorphism is necessary for genetic counseling of patients for themselves and family members.1