INFINITI Warfarin Assay

  • The INFINITI Warfarin Assay is CE Marked.
  • The INFINITI Warfarin Assay is indicated for use to identify individuals at risk for sensitivity to Warfarin.
  • The INFINITI Warfarin Assay utilizes the Warfarin Assay Intellipac, Warfarin Assay Amplification Mix and the Warfarin Assay BioFilmChip Microarray.
  • The INFINITI Warfarin Assay is automated by the INFINITI Analyzer.
Analytes Detected: 
  • 2C9 Variants: *2, *3
  • Clinical Relevance: *2, *3 are the commonly identified 2C9 variants shown to decrease enzymatic activity1
  • VKORC1 Variants: 3673(-1639G>A)
  • Clinical Relevance: 3673 = (-1639G>A) is the commonly identified VKORC1 variant and could be predictive of an individual's response to Warfarin.1
  • Multiplexed determination of 3 genetic variants on one BioFilmChip Microarray
  • Rapid turnaround time enhances workflow efficiency
  • Load & Go automated on the INFINITI/INFINITI PLUS Analyzer.
  • Replicate determinations on a single BioFilmChip Microarray ensures quality results.
Sample Type and Volume: 
  • Requires 0.2 – 2.0 ml of peripheral whole blood in EDTA (purple-top) tube
  • 50 ng DNA / reaction
Clinical Relevance: 
  • Warfarin is the most widely prescribed oral anticoagulant that acts by inhibiting vitamin K-dependent coagulation factors.1
  • Warfarin is used to treat various disorders, including venous thrombosis, atrial fibrillation, pulmonary embolism, acute myocardial infarction and following heart valve replacement.
  • In the US, more than 3,000,000 new prescriptions are being written every year, and the total number of warfarin prescriptions has increased by 45 percent between 1999 and 2004.1
  • There is greater than a ten-fold interpatient variability in the response to Warfarin.1
Clinical Utility: 
  • Warfarin exposes patients to increased risk of hemorrhage.1
  • Annual incidence of associated major-bleeding complications has ranged from 1.0% to 5.0%.
  • Annual incidence of fatal hemorrhages has been reported as 0.5% to 1.1%. 11
  • Major bleeding occurred during the first 90 days of treatment in 50% of patients.1
  • Adverse effects of warfarin treatment account for 15 percent of all severe adverse effects.1

1. Fanikos, John, et. al. Major bleeding complications in a specialized anticoagulation service. American Journal of Cardiology. 2005; 96: 595-98.

Infiniti Warfarin Assay CE