INFINITI Warfarin Assay (IVD)
Sample Type and Volume:
- Warfarin is the most widely prescribed oral anticoagulant that acts by inhibiting vitamin K-dependent coagulation factors.
- Warfarin is used to treat various disorders, including venous thrombosis, atrial fibrillation, pulmonary embolism, acute myocardial infarction and following heart valve replacement.
- In the US, more than 3,000,000 new prescriptions are being written every year, and the total number of warfarin prescriptions has increased by 45 percent between 1999 and 2004.1
- There is greater than a ten-fold interpatient variability in the response to Warfarin.1
- Warfarin exposes patients to increased risk of hemorrhage.
- Annual incidence of associated major-bleeding complications has ranged from 1.0% to 5.0%.1
- Annual incidence of fatal hemorrhages has been reported as 0.5% to 1.1%. 1
- Major bleeding occurred during the first 90 days of treatment in 50% of patients.1
- Adverse effects of warfarin treatment account for 15 percent of all severe adverse effects.1
- Fanikos, John, et. al. Major bleeding complications in a specialized anticoagulation service. American Journal of Cardiology. 2005; 96: 595-98.